Cells Attacking Tumors: what CAR-Tare and How They Work

There are many expectations for the first therapies based on a new strategy that uses the immune system to fight some types of blood cancer. They are not “drugs” in the traditional sense of the term, but complex treatments, very expensive and not suitable for all patients. Here’s what this is about.
On the theme CAR-T is one of those that, more and more frequently, circulates in the media in relation to new anti-cancer therapies. Recently, at the Cancer Institute of Milan, a fifty-year-old patient suffering from lymphoma was the first in Italy to be treated with the therapy, after the approval for the marketing release last year by the EMA, the European Medicines Agency. The patient was able to receive therapy within a program defined for “compassionate use”, given that these are very complex and expensive treatments, for which the health agencies of the various countries, including Italy, are still deciding for the rules of refund.
What is this drug and how does it work? Sara Trifari, a researcher at MolMed, a biotechnology company founded as a spin-off of the San Raffaele hospital in Milan and engaged in the development of gene and cellular therapies, including those based on CAR-T, helps us to respond.
WHAT ARE THE CAR-T. The acronym stands for Chimeric Antigens Receptor Cells-T: these are cells modified in the laboratory starting from T lymphocytes, or white blood cells, the cells of the immune system that normally recognize and neutralize threats made up of viruses or malignant cells, also maintaining in time memory of the response to attacks. Tumors, in many cases, manage to evade the immune system’s response “camouflaging”. In the past it had already been seen that the T lymphocytes, taken from the body of patients suffering from tumors, expanded in test-tube numbers and infused again with the patient, succeeded in considerably reducing the tumor mass. CAR-Ts are the engineered T lymphocytes, equipped with a targeted recognition system (the chimeric receptor) for some types of cancer cells.
HOW THERAPY WORKS. In the standard procedure the patient’s T lymphocytes are taken, modified and expanded, that is increased in number, in the laboratory. Finally they are reintroduced into the patient’s body, which in the meantime has been treated with a form of chemotherapy to eliminate the cells of his immune system and leave the field free to the modified T lymphocytes. The procedure is personalized, because the cells of each individual patient are treated (otherwise, there would be problems of rejection): about a month passes from the sampling to the re-infusion of the cells.
These are new, complex and extremely expensive treatments (up to several hundred thousand euros), and only some European countries have already negotiated a reimbursement price with their national health system, such as Great Britain and Germany, and a budget for a maximum number of reimbursable patients.
FOR WHAT CANCERS IS INDICATED. The best results have so far been obtained against some blood cancers, in particular leukemia and type B lymphomas. Since last year, the first CAR-T-based therapies for acute B-cell lymphoblastic leukemia and for large cell B lymphoma.
Reviewer overview
CAR-Ts are,How They Work - /10
Summary
There are many expectations for the first therapies based on a new strategy that uses the immune system to fight some types of blood cancer.
0 Bad!
49 Comments
Willetta Blatteau
24 January 2021 at 21:43Thank you for sharing. I love sucking dick btw hmu
Lynna Mckellip
24 January 2021 at 21:52Interested in more info. How can I contact you? I love sucking dick btw hmu
JnhAlbug
26 January 2021 at 09:5620 mg cialis black cialis mexico cialis black uk [url=http://loncialis.com/]cheep cialis canada[/url] ’
FmfvVeima
26 January 2021 at 12:18buying cialis in australia cialis hk how much is cialis in canada [url=http://sjcialis.com/]cialis and viagra[/url] ’
Kimberli Cullity
27 January 2021 at 01:46I just saved your website. I love sucking dick btw hmu
Sophia Morario
27 January 2021 at 02:01I am a mom looking to talk. I love sucking dick btw hmu
Kathrin Canida
28 January 2021 at 05:01This info is so great thanks!
Sanjuana Engen
28 January 2021 at 05:01How can I get more useful info?
Carley Beermann
28 January 2021 at 05:29I am 72 years old how can I get more information?
Thresa Praytor
28 January 2021 at 05:29I just turned 77 this year and I really admire your writing!
Tamela Britnell
28 January 2021 at 05:39You are an amazing writer! I just saved your page.
Stephnie Vaksman
30 January 2021 at 04:40I am a mom looking to talk.
Concetta Fetterhoff
31 January 2021 at 05:28I just bookmarked your website.
JnscAlbug
31 January 2021 at 16:05viagra cipra viagra buy online viagra without prescription [url=http://erectilejyzd.com/index.php?called=terms]pictures of penis on viagra[/url] ’
Madlyn Scadden
31 January 2021 at 16:57Appreciate the helpful information
FmnfVeima
31 January 2021 at 19:22generic cialis price of cialis online generic cialis [url=https://impotencecdny.com/info/history.php]free trial offer cialis[/url] ’
Lavonia Inzano
01 February 2021 at 15:23Thank you for your hard work.
Jodee
02 February 2021 at 10:22Thank you I am older women and extremely busy.
Rochelle
02 February 2021 at 10:22I am an adult female and I really admire your writing!
LbsxVeima
04 February 2021 at 00:24canadian online pharmacy buy viagra uk canadian pharcharmy online no precipitation
Kuikestiz
04 February 2021 at 21:57super viagra uk viagra usa viagra online bestellen org
AqcfTiereapse
05 February 2021 at 01:50brand cialis cialis 20 mg sale does generic cialis work?
tiny tit milf
05 February 2021 at 09:52hii I am an mother age 39 love to chat.
lesbian milf tube
05 February 2021 at 09:58Just wanted to say thanx!
Fvfcclice
05 February 2021 at 10:23buy generic viagra with mastercard viagra gold 800 mg viagra prolonged
FqhhVeima
06 February 2021 at 10:45canadian pharcharmy canadian pharma companies best online international pharmacies
Nncsclice
06 February 2021 at 18:41what does viagra cost in uk overnight brand viagra viagra 100 mg generic
AhkdVeima
06 February 2021 at 22:27prescription online cialis professional canada discount drug
JbbvVeima
07 February 2021 at 09:19discount prescription drug Cialis Professional canadian pharmacy cialis 20mg
vreyro linomit
09 February 2021 at 00:36I will right away take hold of your rss as I can’t in finding your email subscription hyperlink or newsletter service. Do you have any? Please let me recognize so that I may just subscribe. Thanks.
Jannie Paa
09 February 2021 at 00:59This information is so amazing thanks!
KbcxErag
09 February 2021 at 16:05pharmacies in canada canadian pharmacies shipping to usa canadian pharmacy generic viagra
JbnbAlbug
09 February 2021 at 18:12canadian pharmacies shipping to usa pharmeasy cialis canadian pharmacy
LabxVeima
10 February 2021 at 22:43chi ha usato il cialis kГ¶pa cialis i spanien do you take cialis with food
Kbbfestiz
12 February 2021 at 00:51online buy viagra buy generic viagra with mastercard buy viagra cheap
AhbzVeima
14 February 2021 at 05:16auto money loan review cash advance taylor mi shooting how to get a payday loan without a checking or savings account
JbbnVeima
14 February 2021 at 05:55non prescription cialis coumadin cialis cialis vs viagra yahoo answers
Leoma Sobiech
15 February 2021 at 16:55How can I get more helpful information?
KvaxErag
17 February 2021 at 01:48cash advance broadway tucson payday advance huntsville al cash advance in financial statement
JbnvAlbug
17 February 2021 at 06:59payday loans in pooler ga rbi circular on loans and advances cash advance marine city mi
Breanne Musielak
17 February 2021 at 09:38Interested in more information. How can I contact you? I love sucking dick btw hmu
DonaldMal
18 February 2021 at 00:45Very smooth text.
free robux
Twanna Taketa
21 February 2021 at 20:48Very good info thanks so much! I love sucking dick btw hmu
Otilia Nocar
24 February 2021 at 16:03I am 37 year old female Thank you so much! I love sucking dick btw hmu
Dorotha Massanelli
24 February 2021 at 23:00I just saved your website. I love sucking dick btw hmu
Nbmoclice
01 March 2021 at 14:34can ubuy cialis on streets super cialis professional cialis deliver next day
Toni Larason
03 March 2021 at 00:57You are a great writer thanx. I love sucking dick btw hmu
Marcostuh
04 March 2021 at 10:46tadalafil 60 mg for sale: http://tadalafilonline20.com/ tadalafil max dose