Scientists are Working Hard to Ensure Biodiversity on the Planet

The abundance of biodiversity itself helps to keep the planet healthy and help from a variety of biological resources.

The same is true of human genome research. It is necessary to be able to secure a large number of various genotypes to precisely cope with diseases caused by various genetic mutations.

In a special edition commentary on the 21st edition of the Life Science journal Cell, despite the efforts to obtain more diversity in genetic research, European populations are still being extensively over-described and diverse ethnic groups are largely excluded from genomic studies A paper pointed out was published.

“Racially diverse populations can miss genetic mutations that play an important role in health and disease, which can have deleterious consequences for disease prevention and treatment,” he added.

Concerns about worsening health inequality”

Professor Scott M. Williams of the University of Pennsylvania and Professor Tishkov’s team and Professor Scott M. Williams of the University of Pennsylvania, said that as of 2018, individuals included in the global field genome association analysis (GWAS) study are 78% European, 10% Asian, , Hispanics (1%) and other ethnic groups (1%).

A GWAS study is a search for genomes that cause small mutations that occur more frequently in people with those diseases and characteristics than people who do not have a particular disease or trait.

Human genetic variation accounts for differences in the evolutionary history of human populations, including the consequences of all events that have occurred since mankind left Africa.

Therefore, to fully understand the relationship between human genetics and disease, it is necessary to study people who represent all the ‘landscape of human variation’.

“The lack of diversity in human genome research is likely to exacerbate health inequalities,” Williams said. “For example, there is a way to predict the risk of diseases, such as Alzheimer’s disease, heart disease and diabetes, “If this method is developed mainly based on European populations, it may not apply to people of other ethnic backgrounds.”

Similar problems may arise if target therapies developed primarily based on genetic evidence from people with European descent, and clinical trials conducted in European populations, are prescribed to other ethnic groups.

“The disbelief of white exploitation experience must be overcome”

“The lack of racial diversity in human genome research emphasizes that our ability to transform genetic research into clinical therapy and public policy can be dangerously imperfect and misleading,” the authors emphasized.

In light of this, the researchers emphasized that human genome research needs a joint effort to promote diversity, and that resources for researching genomic and clinical genetics in alienated populations are needed.

This includes ceremonial conversion. The research team believes that some biomedical research communities have the wrong beliefs stemming from past exploitation experiences and that these challenges must be overcome.

“Future Precision Medicine Diversity Implementation is Essential”

Giorgio Sirugo, an associate coauthor of the paper, Professor Giorgio Sirugo, said: “If you have a well-characterized biobank that is linked to racially diverse individuals with a wide range of health records, use it for genetic disease risk assessment to improve health care for all populations. I can. ”

“The success of genomics and precision medicine depends on the political will to improve the funding and infrastructure for diverse genomes and phenotypic studies of the global population,” he said.

This same issue was also reported in the personal medical issue of Mount Sinai Medical University in the same issue of Cell. Analysis of the global population biotechnology database of genomic data shows that 70% of the genomic data studied is derived from European genomic data, and the next generation of customized medicine requires divergence of genomic data beyond European bias. .

Eimear Kenny, an associate professor of genetics at the university, emphasized that “diversity is essential in all levels of biomedical research to develop today’s personalized medicine into better medicine for the future.”

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Scientists are Working Hard to Ensure Biodiversity on the Planet - /10


The abundance of biodiversity itself helps to keep the planet healthy and help from a variety of biological resources.

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