Vermifuge and Asthma Medicine can Kill Coronavirus in Laboratory

Korean researchers identified the drugs after testing 46 substances that are already used to treat other diseases.

South Korean researchers have identified two more drugs that have shown promising signs against the new coronavirus in laboratory tests. The two drugs proved to be able to beat the causer of Covid-19 in tests done with cells in laboratories.

Both drugs have already been approved in the United States to treat other diseases, which should facilitate their use against Covid-19. However, the results, the scientists note, are still preliminary and tests have not been done on humans. The research was published in Antimicrobial Agents and Chemotherapy, a specialized journal of the American Society for Microbiology.

For the study, the researchers tested 46 drugs (all already used to treat other diseases) on Vero cells, a strain developed from kidney cells of the African green monkey. These cells are commonly used in the cultivation of viruses for the production of vaccines.

One of the medications is the vermifuge niclosamide, which is used for the treatment of teniasis. “It is not surprising that its broad-spectrum antiviral effect has been well documented in the literature, including antiviral properties against SARS (severe acute respiratory syndrome) and MERS-CoV (Middle East respiratory syndrome),” the authors say in a press release.

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Despite the positive results, the authors highlighted that a disadvantage of niclosamide is its low absorption by the body.

The other medication is the antiviral ciclesonide, an inhaled corticosteroid used to treat asthma and allergic rhinitis. “With its proven anti-inflammatory activity, ciclesonide may represent a potent drug that can manifest [the] dual roles [of antiviral and anti-inflammatory] in controlling SARS-CoV-2 infection,” conclude the researchers.

American and Hong Kong researchers have already managed to identify about 30 drugs that show effectiveness against Covid-19. All of them are candidates for drugs to treat the new coronavirus. Three are currently in clinical trials for Covid-19.

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Vermifuge and Asthma Medicine can Kill Coronavirus in Laboratory - /10

Summary

Korean researchers identified the drugs after testing 46 substances that are already used to treat other diseases.

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