Researchers from Bnei Zion Medical Center in Haifa, in collaboration with the Technion, have developed a molecule that regulates the activity of the immune system, and could be  the future solution for many patients. This is what you need to know about…

Autoimmune diseases are one of the great challenges of the medical world, and they have become more and more common in recent decades. These diseases are caused by an imbalance in the activity of the : overactivity of the system on the one hand, and a marked decrease in the ability to control the immune system on the other hand. Overactivity of the immune system is manifested in increased production of inflammatory factors called inflammatory cytokines and in the production of antibodies against autoimmune components.

This mechanism causes the development of chronic inflammatory diseases such as rheumatoid arthritis, lupus and allergic diseases such as asthma. These are diseases that start at a young age, last for many years and cause considerable suffering and a decrease in the quality of life and more. Traditional treatments for autoimmune diseases are steroids and cytotoxic drugs, but these have multiple side effects, including obesity and bone marrow suppression. Therefore, researchers are trying to find other ways to deal with them.

In a long-term study of the control mechanisms of the immune system, conducted at Bnei Zion Medical Center in Haifa, in collaboration with the Technion, the groundbreaking thought was raised that a change in attitude could bring the good news: And in this way reduce the overactivity of this system.

The research team, led by Prof. Emeritus Clinical Elias Toby (former director of the Department of Clinical Immunology and Allergology at Bnei Zion Medical Center), Prof. Zehava Woods, Director of the Proteomics Unit, etc. The Director General of the Bnei Zion Medical Center and Prof. Gera Neufeld from the Faculty of Medicine at the Technion, have developed a new molecule that has been found in their research as a molecule that regulates the activity of the immune system.

This molecule is called semaphorin 3A, and has been found to be very effective in maintaining the balance of the immune system (homeostasis). When this balance is disturbed – in autoimmune diseases but also in inflammatory diseases – the level of production and secretion of semaphorin decreases significantly. The low level of samapurin, allows for the increase of the inflammatory response, and the creation of continuous damage to the various tissues. When samapurin is artificially returned to the immune cell cultures of patients with these diseases – their increased function, and excessive cytokine secretion are reduced and the immune system balance returns to normal.

The researchers tested their discovery in models from mice that mimic these diseases. When samapurine was injected into mice mimicking lupus, their condition improved significantly: kidney damage was prevented, and rapid mortality was avoided. These results formed the basis for the development of an engineered molecule that would constitute future treatment for these diseases, the researchers hope.

“Is there a solution to autoimmune diseases?”: Of course not. Again “research” on you, pretentious, a puffy title empty of content. After all, every child, an immunologist, knows and understands that this is a variety of dozens of diseases, which are almost similar in nothing, in the target organs, cells and mixed organs, and complex and unrelated mechanisms. Another pretense, which will glorify the advertisers ….

It’s time to invest in research of various kinds for human welfare than in destructive nonsense from weapons to games and dumb apps that donate nothing but money that goes on for a little while!