The Treatment of Viral Diseases

Comprehensive news from different sources is said to have worked with drugs such as Kaletra, Tamiflu, and interferon. On the other hand, the effectiveness of the RAM receiver is also being verified. Their names are somewhat unfamiliar. It’s often because they’re the same “antiviral,” rather than the antibiotics we use for bacterial infections.

Kaletra, originally used to treat AIDS, is a combination of lopinavir and ritonavir. Tamiflu (oseltamivir) is a well-known influenza (flu) drug known to us, and interferon is a biological immune protein that is also used as an anticancer drug. Remdesivir is a drug used to treat Ebola and Marburg virus infections.

How did doctors think of these drugs for the first outbreak of new coronavirus infection? Even now, the experiences we have experienced during the MERS affair (2015) that is vivid in our memory would have been important. MERS Incident used the 2003 SARS as a teacher. SARS and MERS are both caused by the corona virus and appear to be the first to introduce antiviral drugs that have been effective during the MERS outbreak.

At the end of the 20th century, there were few antiviral drugs that doctors could prescribe in hospitals. At most, acyclovir was used for patients with herpes encephalitis or shingles. But over the generations, various antiviral drugs have emerged. It is now common sense to prescribe Tamiflu to the flu (influenza), which even says there is no medicine. Viral hepatitis, which plagued Koreans, is also treated with antiviral drugs.

To date, about 90 drugs have been approved as antiviral drugs. This does not mean that 90 viral diseases can be cured. So far, there are medicines that can only be used for nine viruses. The virus is herpesvirus (HSV), human immunodeficiency virus type 1 (HIV-1), cytomegalovirus (CMV), influenza virus, hepatitis B virus (HBV), hepatitis C virus (HCV), chickenpox- Herpes zoster virus (varicella-zoster virus), respiratory syncytial virus (RSV), human papilloma virus (HPV).

As a result, there is no drug for rhinoviruses, which causes the most common cold among viral diseases. More than 200 viruses are known to cause illness in humans, but they are still in short supply.

Antibacterial to attack bacteria first appeared in 1910, and since the 1940’s has been poured out. Since World War II, the drugs we call antibiotics have poured out innumerablely. Scholars studying microbiology and infectious diseases can be divided into pre- and post-antibiotic periods before and after this period.

But the history of antiviral drugs is far behind. The first antiviral drug was idoxuridine, which appeared in 1961. The drug was developed as an anticancer drug in the 1950s and then changed to a drug for the treatment of herpes eye disease.

Since then, vidarabine (1960), trifluridine (1964), amantadine (1964), ribavirin (1972), acyclovir (1971), and the first treatment for AIDS Azidothymidine (AZT, 1985), valaciclovir (1987), famciclovir (1989), lamivudine (3TC, 1989) were attackers.

Lopinaver (lopinavir (1998)), ritonavir (1996), and oseltamivir (1997), now used for new coronavirus infections, were discovered at the end of the 20th century. Interferon, also used as an anticancer agent, is a historic drug discovered in 1954. Remdesivir, currently being tested for therapeutic efficacy, was the first antiviral drug used during the 2013 Ebola epidemic.

Most antiviral drugs only listen to a particular virus, a virus of a particular subtype or genotype. In other words, you can’t eat pork but usually stick with black pork from Jeju Island. However, very few antiviral drugs are heard throughout many viruses. Acyclovir, balaciclover, and famciclovir, which are used for herpes and shingles, are good at eating. It is also good for lamivudine, which is used to treat AIDS, and ribavirin, which is used for hepatitis and influenza. Even so, the effect is limited to a few viruses.

In that sense, the drugs used or tested for efficacy are those used for AIDS, influenza, MERS, and Ebola. Of course, it is important to develop new drugs, but on the one hand, it is very important that some kind of recycling be used to find new uses from existing drugs. This is especially true given the time and cost of developing a new drug.

Is there human defense against viruses other than antiviral drugs? Not necessarily. By developing a vaccine, you can fight viruses in an easier way. Hepatitis, uterine cancer, shingles, chicken pox, influenza, polio, Japanese encephalitis, yellow fever, mumps, measles, rubella, and rabies are prevented by vaccination.

The greater the understanding of the virus, the more therapeutics and vaccinations are expected. But there is one fact that cannot be overemphasized. The strongest forces to fight the virus are personal health and immunity. This is not done in a short time. You will usually have to develop healthy lifestyles and self-care.

 

Reviewer overview

The Treatment of Viral Diseases - /10

Summary

Comprehensive news from different sources is said to have worked with drugs such as Kaletra, Tamiflu, and interferon.

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