This is how the Third Dose of Vaccine will Affect the Body

Israil’ Ministry of Health has published new findings that the effectiveness of Pfizer’s vaccine in preventing infection has decreased, although the vaccine is still very effective in preventing serious illness and hospitalizations.   Israel’s Ministry of Health will recommend giving a third dose to those with a weakened immune system, but it may be recommended that other sections of the population receive a third vaccine. What makes another dose in the body and why the vaccine is weakened.

Israel said the delta variant is blunting the effectiveness of BioNTech and Pfizer’s COVID-19 shot, but how well a vaccine works is going to fluctuate in the real world and a single data point may not tell the whole story.

The Delta variant continues to take over the world and overcomes the vaccine: New findings from the Ministry of Health reveal that the effectiveness of infection protection among vaccinated people has decreased due to the Delta strain of the corona virus, although the vaccine is still highly effective against serious illness and hospitalizations. Based on the findings, the Ministry of Health is about to recommend a third impulse for those with a weakened immune system.

Why is the vaccine less effective, who caused the spread of the Delta strain in the world, will we all end up with a third dose and what is it likely to do in the body?

What have the latest findings in Israel shown?
The Ministry of Health monitors the usefulness of the vaccine against the corona virus on a regular basis. An epidemiological analysis of public health services at the Ministry of Health, starting June 6, shows that there is a decrease in the effectiveness of the vaccine in preventing infection to 64% and in preventing disease with symptoms to 64%. The decline was observed simultaneously with the spread of the Delta variant in Israel. However, the effectiveness of the vaccine in preventing hospitalizations and severe morbidity in the corona virus remained high at 93%.

Will we need a third dose of vaccine?
There has long been talk in the world about giving a third dose of vaccine, which should improve immune protection and perhaps reduce the rate of infections that have also been found in vaccinated people. This is not a new invention: many vaccines require a booster dose – another dose that is renewed once in a while, to “bounce back” the level of antibodies, those soldiers of the immune system who are supposed to protect against foreign invaders, and in our case – against the corona virus.

It is estimated that in some vaccines, antibody levels decrease after a few months of vaccination, leading to the assumption that a third vaccine will re-bounce the antibodies to a high level, reducing the risk of infection. This hypothesis is still being tested in Pfizer and Moderna, which have not yet published their findings. However, at least according to data released by Pfizer, it seems that a third booster dose (also called Boost) may indeed increase protection against corona infection.

The Ministry of Health has already announced that it may soon recommend giving such an impulse dose to those with a weakened immune system. The ministry has not yet determined the exact criteria that will define who is in this group, but it must be assumed that these are elderly people over the age of 65, and those who suffer from immunosuppressive diseases. It is possible that according to the monitoring of morbidity levels in Israel, and the measurements of antibody levels carried out by the vaccinated who have undergone frequent blood tests – the ministry will recommend adding additional population groups who will receive a third booster dose.

Why is the vaccine less effective?
Corona viruses, like other viruses, constantly create mutations as part of an evolutionary survival mechanism designed to spread and multiply as much as possible, while creating resistance mechanisms. The corona virus constantly creates mutations, some of which fail in the task of spreading, the complex and “sophisticated” mutations manage to overcome various barriers, such as the vaccine barrier, to infect faster.

Current Pfizer vaccines have not yet been adapted to the new variants, so it is likely that new mutations will begin to show resistance and overcome the original vaccine. The advantage of Pfizer and Modernna vaccines, built with mRNA technologies, is that it is very easy to create a “version update”. Such a process lasts only six weeks, at the end of which a vaccine adapted to each new viral strain can be created.

As early as last February, Pfizer announced that it was beginning an experiment with vaccines adapted to the various variants, including the Delta variant. The company maintains a heavy veil of secrecy regarding the trials it is conducting on the vaccines, and has not yet released the findings, but it is likely that in the coming months it will update the vaccine to suit all recent versions discovered, and most likely newer versions.
Prof. Galia Rahav to Ynet Studio: “It is not far off today that a third dose will be given”

What causes the variants to spread?
According to estimates, the variants are formed and spread in the bodies of unvaccinated people, who actually become a “mutation factory”. The viruses infect them, spread through their bodies, and constantly create more and more mutations, some of which are released back and infect others. Thus the variants multiply, so that the only way to stop their formation and spread is to vaccinate the world population, and as quickly as possible.

Will we ever be able to overcome the corona?
The corona will probably accompany us for many more years, and will become, after the end of the vaccination of the world population, a disease that “lives with it”, similar to the flu. It is hard to believe that the virus will become extinct in the coming years, but the development of vaccines and antiviral drugs that may succeed in killing the virus will lead to a less contagious, less deadly disease, at least – until the next epidemic.