Scientists at the Francis Crick Institute have been able to shoot 3D images of pancreatic cancer early in the day.

The early developmental process of pancreatic cancer was one of the mysteries that the medical community had not been able to solve. Environmental factors and genetic factors were thought to be caused by combined action, but this was only an estimation.

To solve this problem, the Francis Creek research team put in new equipment to reproduce the tissue as 3D stereoscopic images. And we were able to closely observe how pancreatic cancer cells grow and grow.

The team said they could use the device to collect a variety of information from cellular tissue, as well as improve treatment methods for pancreatic cancer.

The device was developed by the Princeton Creek Institute in partnership with the European Research Council (ERC), Cancer Research UK, the British Medical Research Council (M RCl), and the International Charity Foundation Wellcome Trust.

A related research paper was published in the journal Science Nature. The title of the paper is ‘Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis’.

The pancreas secretes enzymes involved in digestion with a 15 cm long organs located in the posterior retroperitoneum of the stomach, digesting the food we consume. Diabetes can also occur if the function is impaired because it secretes a hormone called insulin.

However, there is no developed method to detect pancreatic cancer early. They are doing ultrasound endoscopy for people with a family history, people with diabetes, chronic pancreatitis, and smokers who are at high risk for developing pancreatic cancer.

The site of pancreatic cancer is the connection site to other digestive organs. Previously, the researchers have collected cancer cells at this site and analyzed them using 2D equipment.

However, it was not enough to analyze the developmental mechanism of this pancreatic cancer cell, which has various and bizarre appearance.

Hendrik Messal, co-author of the paper, Francis Crick, MD, said, “We have been developing new equipment for more precise analysis of pancreatic cancer tissues over the last six years, Equipment, “he said.

Can be applied to other cancers such as lung cancer and liver cancer

Previous 2D images have confirmed the size of pancreatic cancer according to the thickness of the intestine. It was there.

“But this 3D image shows that cancer develops in two of the first forms of pancreatic cancer,” Dr. Mesal said.

On the other hand, it propagates internally to other structures in the pancreas while endogenous endophytic growth, and on the other hand it externally expands its area while exophytic growth.

The researchers also confirmed that the size of pancreatic cancer may be less than 20 mT (㎛, 1 millionth of a meter), but can grow to ¼ of a millimeter.

The 3D image equipment developed by the institute has been equipped with computer analysis equipment capable of digesting big data and high-tech imaging equipment.

Dr. Silvanus Alt, biophysicist, co-author of the paper, explained, “By using this device, we can grasp the structure of individual pancreatic cancer tissues, and it becomes possible to analyze and evaluate the shape of cancer cells precisely.” .

Dr. Axel Behrens, who participated in the development of the equipment, said, “The development of 3D imaging equipment will play a very important role in the diagnosis of cancer in the future.”

“The future of pancreatic cancer and other cancers can be understood biophysically,” Dr. Berins said. “The process of acquiring this information has opened the way for new treatments not only for early cancer but also for terminal cancer” He said.

Researchers are now looking for ways to early detect cancer by applying the device to other organs. Especially lung cancer and liver cancer.

Dr. Guillaume Salbreux, Ph.D., found, “In the process of analyzing pancreatic cancer, we found a process in which a defective cell develops into cancerous cells.” When applied to other cancer diagnoses, I can do an early diagnosis of cancer, “he said.

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