Stress, Mother, Pregnancy and Fetus

President of the Weizmann Institute: “Stress affects the wiring of the brain, there is a connection between the stress of the mother in pregnancy and the diseases in adulthood”.

Prof. Alon Chen, a neurobiologist and stress researcher who took up his post as president of the Weizmann Institute, reveals in an interview with “Lady Globes” that “what affects the durability of the baby”.

Imagine for a moment that you are on a safari vacation in Africa. After a long day in which you have watched animals in their natural regions, you arrive at the Lodge where you spend the night. After dinner you sit on the porch chatting with another tourist, and then suddenly a look of panic appears on his face. You turn your head and see that lion enters the area where you sit.

“We will all see the lion as a threat, and as soon as we perceive this threat, the brain will activate the survival response to stress situations, such as changes in the levels of fear and anxiety, decreased appetite, changes in memory and attention, Blood pressure, blood sugar, and hormone cortisol, which is released in the body during stress, “he explains.
Prof. Alon Chen, president-elect of the Weizmann Institute of Science, in an interview with Lady Globes.

“The person who sees a lion entering a room will have a high blood sugar level, because the body ‘takes into account’ that it is now necessary to run to escape, which requires energy, and in this situation there will be other things: an increase in levels of fear, learning and memory.

“If, for example, it takes 5-10 seconds to notice that the lion is entering, our attention changes significantly following the activation of the brain response to the pressure, and if a tiger enters it, we will notice it in a very short time. At the same time, the appetite and the reproductive system are suppressed, and the immune system enters into action, and in fact most of the centers of the brain change significantly and switch on or off to deal with the threat.

“If, for example, it takes 5-10 seconds to notice that the lion is entering, our attention changes significantly following the activation of the brain response to the pressure, and if a tiger enters it, we will notice it in a very short time. At the same time, the appetite and the reproductive system are suppressed, and the immune system enters into action, and in fact most of the centers of the brain change significantly and switch on or off to deal with the threat.

Are all systems out of balance?

“Yes, in the operation of the brain response to stress situations, most systems come out of equilibrium as long as the lion is present, but if after a few seconds we realize that the threat has passed – for example, if it is not really a lion, but someone who enters a lion costume, and a whole system of neurons and brain circuits, controlled by different genes and proteins, that helps restore all the systems (blood pressure, pulse, sugar, anxiety) to equilibrium, for example, we know that the stress hormone cortisol takes about two hours Return to normal, and there are times when it takes even longer. Emotionally, some people relax quickly And there are those who are less. ”

And when the system does not know how to turn itself off normally?

“It’s a symphony of coordination, one gene that activates the other, which turns off the third, and we already know that if we interfere with these brain circuits, we can make organisms react differently, we can make them not fear at all, or make them very anxious “In recent years we have discovered that there are genes that are responsible for shutting down the response to stress situations, a mouse that does not have these genes will return to normal, to equilibrium within a week, and not after two hours.”

Prof. Alon Chen, head of the Department of Neurobiology at the Weizmann Institute of Science, has been studying the mechanisms of stress and brain reactions that he is arousing for 17 years. “The broader definition of stress is ‘the result of any challenge of your equilibrium system.'” This means that the stressors are very diverse, they can be completely psychic, or they can be physiological, but both will run similar and sometimes even similar brain and nervous systems. If in healthy people the blood sugar level is 100, in people under pressure, the level can be 160-180, only because of the activation of the brain response to stress and threat.

Chen tells about a lecture he gave a few years ago in an old, age home where people who lived through World War II. “When I said that modern life is very stressful and some define it as an epidemic, the elderly looked at me and said, ‘Modern life is stressful, you know what we went through in the 1940s, there was nothing to eat, there were no medicines, there was nothing.’ This pressure is a matter of perception, it is something very individual and time-matched, and if we take the cell phone, we are afraid that we will not be able to talk to the children’s caretaker for a few hours.

This means that pressure is also a social matter.

“The social fabric has a great influence on the pressure factors and on our response to stress, for example, social networking is a terrible stressor that did not exist until a decade ago, and it is important to remember that different people perceive things differently. Some people will pick up and react to stress differently, depending on the background, early exposure and level of matching, that is, if every day a lion enters you into the room and you realize that he is just turning around, you will no longer activate the pressure response the same thing at work, if you are exposed to the same every day, you will develop mechanisms that will reduce your reaction To the pressure factor. In the end, learning and exposure greatly affect the response. ”

The factors that determine how we respond to stress and how we deal with it during life are determined, in part, at the embryonic stage. “Stress has an impact on our brain wiring during development,” Chen explains. “We also know that stress during pregnancy can lead to premature birth and increase the risk that the fetus will develop adulthood in both metabolic and mental illnesses, such as depression and anxiety.

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